The effect of corticotropin on mouse spleen colony-forming cells.

Several investigators have reported a retechnique. There was a marked decrease duction in the number of colony-forming in spleen CPU in these mice when cornunitsjCFU) in the sple.ns of mice exposed pared with control animals, but marrow to hypoxia and have postulated that this is CPU were not reduced. These tesults mdis.condary to a direct toxic effect of hypoxcafe that part of the effect of hypoxemia emia on the CR1. To test the hypothesis on CR1 may be secondary to the stress of that at least part of this effect could be the exposure and suggest that spleen CFU secondary to the stress of the hypoxic cxare sensitive to steroid hormones. Further posure, mice were given 1 2 consecutive investigation of this and other differences daily injections of corticotropin (ACTH), between spleen and marrow CFU could and the number of spleen and marrow lead to a better understanding of stem cell CR1 were assayed by the spleen colony differentiation.